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Nevertheless.it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Sometimes doctors prescribe acyclovir to treat herpes infections in people with HIV.

Fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) of the brain done five days after initiation of aciclovir treatment.showing features consistent with posterior leucoencephalopathy (panels A and B). Repeat MRI five days after discontinuation of aciclovir showed a marked improvement (panels C and D).

In conclusion.the authors state that aciclovir has no impact on the HIV-1 transmission rates in these populations. “Our results show that suppressive therapy with standard doses of aciclovir is not effective in reduction of HIV-1 acquisition in HSV-2 seropositive women and MSM. Novel strategies are needed to interrupt interactions between HSV-2 and HIV-1.” Additionally.they say.that futher studies should be performed to ascertain whether this lack of efficacy is due to drug absorption and metabolism.the clinical response of genital ulcers to the drug.or the persistent genital immune response after HSV-2 is activated.

Your symptoms should improve during your treatment with acyclovir. Call your doctor if your symptoms do not improve or if they get worse.

Take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However.if it is almost time for the next dose.skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Comments . -Acyclovir is the drug of choice for local and disseminated herpes simplex in HIV-infected and exposed infants and children. children with severe immunosuppression and moderate to severe lesions should be treated initially with IV therapy and may require longer therapy. -Immunocompromised patients may have prolonged or severe episodes. clinical manifestations of genital herpes may worsen during immune reconstitution early after initiation of antiretroviral therapy. -CDC STD Treatment Guidelines and the Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV- Exposed and HIV-Infected Children may be consulted for additional guidance.

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