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One case of peripheral neuropathy that resolved on discontinuation of Betapace and recurred when the patient was rechallenged with the drug was reported in an early dose tolerance study.

Hospitalize patients initiated or re-initiated on sotalol betapace over the counter at least 3 days or until steady-state drug levels are achieved.in a facility that can provide cardiac resuscitation and continuous electrocardiographic monitoring. Initiate oral sotalol therapy in the presence of personnel trained in the management of serious arrhythmias. Perform a baseline ECG to determine the QT interval and measure and normalize serum potassium and magnesium levels before initiating therapy. Measure serum creatinine and calculate an estimated creatinine clearance in order to establish the appropriate dosing interval (betapace over the counter cross ref to renal dosing). Continually monitor patients with each uptitration in dose.until they reach steady state. Determine QTc 2 to 4 hours after every dose.

Do not skip doses or stop taking sotalol without first talking to your doctor. Stopping betapace over the counter may make your condition worse. You may need to use less and less before you stop the medication completely.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea.or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance.making it dangerous for you to use sotalol.

Sotalol hydrochloride prolongs the plateau phase of the cardiac action potential in the isolated myocyte.as well as in isolated tissue preparations of ventricular or atrial muscle (Class III activity). In intact animals it slows heart rate.decreases AV nodal conduction and increases the refractory periods of atrial and ventricular muscle and conduction tissue.

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