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Frequency not reportedSuppression of growth in pediatric patientsaseptic necrosis of femoral and humeral headscalcinosisCharcot-like atrophyloss of muscle massmuscle weaknessosteoporosispathologic fracture of long bonespostinjection flaresteroid myopathytendon ruptureparticularly of the Achilles tendonvertebral compression fracturesmyalgiamuscle atrophyosteonecrosisneuropathic arthralgiagrowth retardationRef]

If signs of stress are associated with the condition being treatedthe dose should be increasedIf a rapid hormonal effect of maximum intensity is requiredas in anaphylactic shockthe intravenous administration of highly soluble SOLU-DELTA-CORTEF Sterile Powder containing prednisolone sodium succinate is indicated.

Because of its inhibitory effect on fibroplasiamethylprednisolone may mask the signs of infection and enhance dissemination of the infecting organismHenceall animal patients receiving methylprednisolone should be watched for evidence of intercurrent infectionShould infection occurit must be brought under control by use of appropriate antibacterial measuresor administration of methylprednisolone should be discontinued.

Reactii adverse Tulburari hidroelectroliticeretentie sodatainsuficienta cardiaca congestiva la pacientii susceptibilihipertensiuneretentie lichidianapierderi de potasiu si alcaloza hipokalemicaOsteomuscularemiopatie steroidianaoboseala muscularaosteoporozafracturi patologicefracturi vertebrale prin compresie si necroza asepticaGastrointestinaleulcer peptic cu posibila perforatie si hemoragiehemoragie gastricapancreatitaesofagita si perforatie intestinalaDermatologiceafectarea vindecarii plagilorpetesii si echimozepiele subtiataMetabolicebalanta de azot negativa datorita catabolismului proteicNeurologicepresiune intracraniana crescutapseudotumori cerebraletulburari psihice si convulsiiEndocrinologicetulburari menstrualestari cushingoidesupresia axului hipofizosuprarenalianscaderea tolerantei la carbohidratimanifestarea diabetului zaharat latentcresterea necesarului de insulina sau antidiabetice oralesupresia cresterii la copiiOftalmologicecataracta posterioara subcapsularacresterea presiunii intaroculare si exoftalmieImunologicemascarea infectiiloractivarea infectiilor latenteinfectii oportunistereactii de hipersensibilitateanafilaxie si supresia reactiilor la testele cutanate.

Musculoskeletal Conditions As with other adrenal steroidsDEPO-MEDROL Sterile Aqueous Suspension has been found useful in alleviating the pain and lameness associated with acute localized arthritic conditions and generalized arthritic conditionsIt has been used successfully to treat rheumatoid arthritistraumatic arthritisosteoarthritisperiostitistendinitissynovitistenosynovitisbursitisand myositis of horsestraumatic arthritisosteoarthritisand generalized arthritic conditions of dogsRemission of musculoskeletal conditions may be permanentor symptoms may recurdepending on the cause and extent of structural degeneration.

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