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Fortunately, pre-pubescent girls who undergo cyclophosphamide cytoxan therapy, or chemotherapy, seem to be relatively protected from the treatment s harmful effects on the ovaries.

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Cyclophosphamidealthough effective alone in susceptible malignanciesis more frequently used concurrently or sequentially with other antineoplastic drugs.

CongenitalFamilial and Geneticintra-uterine deathfetal malformationfetal growth retardationfetal toxicityincluding myelosuppressiongastroenteritis

Alopecia occurs commonly in patients treated with cyclophosphamideThe hair can be expected to grow back after treatment with the drug or even during continued drug treatmentthough it may be different in texture or colorSkin rash occurs occasionally in patients receiving the drugPigmentation of the skin and changes in nails can occurVery rare reports of Stevens-Johnson syndrome and toxic epidermal necrolysis have been received during postmarketing surveillancedue to the nature of spontaneous adverse event reportinga definitive causal relationship to cyclophosphamide has not been established.

The prescribing physician is solely responsible for making all decisions relating to appropriate patient care includingbut not limited todrugsregimensdosescheduleand any supportive care.

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