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A review of the safety surveillance database revealed cases of intentional and accidental Zanaflex overdose. Some of the cases resulted in fatality and many of the intentional overdoses were with multiple drugs including CNS depressants. The clinical manifestations of tizanidine overdose were consistent with its known pharmacology. In the majority of cases a decrease in sensorium was observed including lethargy.somnolence.confusion and coma. Depressed cardiac function is also observed including most often bradycardia and hypotension. Respiratory depression is another common feature of tizanidine overdose.

If you need to stop taking either drug.your doctor will slowly lower your dosage over time.

Because clinical studies are conducted under widely varying conditions.adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice.

The need to stagger doses of propranolol has not been established.zanaflex 2mg reviews but may be prudent.

Zanaflex is a central alpha-2-adrenergic agonist indicated for the management of spasticity. Because of the short duration of therapeutic effect.treatment with Zanaflex should be reserved for those daily activities and times when relief of spasticity is most important [see DOSAGE AND ADMINISTRATION ].

Withdrawal symptoms.such as anxiety.tremor.increased blood pressure.heart rate.and muscle tenseness.may occur if you suddenly stop using this medication.

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