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Potassium supplements.potassium-sparing diuretics or potassium-containing salt substitutes and other medicinal products that may cost of zestoretic serum potassium levels.
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The most frequent clinical adverse experiences in controlled trials (including open label extensions) with any combination of lisinopril and hydrochlorothiazide were. dizziness (7.5%).headache (5.2%).cough (3.9%).fatigue (3.7%) and orthostatic effects (3.2%) all of which were more common than in placebo-treated patients. Generally.adverse experiences were mild and transient in nature.but see WARNINGS regarding angioedema and excessive hypotension or syncope. Discontinuation of therapy due to adverse effects was required in 4.4% of patients principally because of dizziness.cough.fatigue and muscle cramps.
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Surgery/Anesthesia. In patients undergoing major surgery or during anesthesia with agents that produce hypotension.lisinopril may block angiotensin II formation secondary to compensatory renin release. If hypotension occurs and is considered to be due to this mechanism.it can be corrected by volume expansion.
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