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Etodolac.like other NSAIDs.through effects on renal prostaglandins.may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine.digoxin.methotrexate.and increased toxicity. Nephrotoxicity associated with cyclosporine may also be enhanced. Patients receiving these drugs who are given Etodolac.or any other NSAID.and particularly those patients with altered renal function.should be observed for the development of the specific toxicities of these drugs. NSAIDs.such as Etodolac.should not be administered prior to or concomitantly with high doses of methotrexate. NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. In general.caution should be used when NSAIDs are administered concomitantly with methotrexate.

Frequency not reported . Photophobia.transient visual disturbance.conjunctivitis [Ref]

Etodolac can increase your risk of fatal heart attack or stroke.especially if you use it long term or take high doses.or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft.or CABG).

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage.including. dark urine.persistent nausea/vomiting/purchase etodolac of appetite.stomach/abdominal pain.yellowing eyes/skin.

(Adverse reactions reported only in worldwide postmarketing experience.not seen in clinical trials.are considered rarer and are italicized.)

Etodolac is eliminated primarily by the kidney. Because elderly patients are more likely to have decreased renal function.care should be taken in dose selection.and it may be useful to monitor renal function (see WARNINGS.Renal Effects).

heart disease.high blood pressure.high cholesterol.diabetes.or if you smoke.

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