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Prothrombin time may be increased in patients receiving concomitant DIFLUCAN and coumarin-type anticoagulants. In post-marketing experience.as with other azole antifungals.bleeding events (bruising.epistaxis.gastrointestinal bleeding.hematuria.and melena) have been reported in association with increases in prothrombin time in patients receiving fluconazole concurrently with warfarin. Careful monitoring of prothrombin time in patients receiving DIFLUCAN and coumarin-type anticoagulants is recommended. Dose adjustment of warfarin may be necessary. (See CLINICAL PHARMACOLOGY . Drug Interactions Studies .)
Although not specifically studied.fluconazole has the potential to increase the systemic exposure of other NSAIDs that are metabolized by CYP2C9 (e.g..naproxen.lornoxicam.meloxicam.diclofenac). Frequent monitoring for adverse events and toxicity related to NSAIDs is recommended. Adjustment of dosage of NSAIDs may be needed.
In addition.the following adverse events have occurred during post-marketing experience.
fast or pounding heartbeats.fluttering in your chest.shortness of breath.and sudden dizziness (like you might pass out).
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